Eosinophilic granuloma, also known as Langerhans cell histiocytosis, generally refers to a localized form of histiocytic proliferation confined to the bone. It is classified as a type of Langerhans cell histiocytosis. It is more commonly seen in adolescents and often occurs in sites such as the skull, ribs, spine, and scapula. Lesions in long bones are typically found in the metaphysis or diaphysis, with solitary lesions being more common.
Clinical Features
Pain and swelling are present at the affected site. Radiographically, it appears as a solitary and well-defined lytic lesion, which may be eccentric and associated with periosteal reaction. In the spine, eosinophilic granuloma may manifest as vertebra plana (flattened vertebra).
Treatment
Both curettage with bone grafting and radiotherapy are effective treatment options.